Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice.

ABSTRACT:

Background

Integrins, important extracellular matrix (ECM) receptor proteins, are affected by inflammation and can participate in the maintenance of many painful conditions. Although they are ubiquitous and changeable across all cell types, the roles of these cell adhesion molecules in pathological pain have not been fully explored.

Objective

We evaluated the effects of the subcutaneous injection of lebecetin, a C-type lectin isolated from Macrovipera lebetina snake venom, previously reported to inhibit α5β1 and αv integrin activity, on different components of inflammation induced by the formalin administration in the hind paw of mice.

Methods

The formalin-induced nocifensive behavior, edema, and histopathological changes in the hind paw associated with cytokin

SUBMITTER: Belardo C 

PROVIDER: S-EPMC11092918 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature