Dementias Platform UK: Bringing genetics into life.

ABSTRACT:

Introduction

The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is poorly understood. The DPUK collection of independent cohorts can facilitate research in neurodegeneration by combining their genetic and phenotypic data.

Methods

For genetic data processing, pipelines were generated to perform quality control analysis, genetic imputation, and polygenic risk score (PRS) derivation with six genome-wide association studies of neurodegenerative diseases. Pipelines were applied to five cohorts.

Discussion

The data processing pipelines, research-ready imputed genetic data, and PRS scores a

SUBMITTER: Leonenko G 

PROVIDER: S-EPMC11095482 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature