Photo- and Cu-Mediated ¹¹C Cyanation of (Hetero)Aryl Thianthrenium Salts.

ABSTRACT: We present a photo- and Cu-mediated ¹¹C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.

SUBMITTER: Cheng K 

PROVIDER: S-EPMC11099534 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature