Potential clinical impact of predictive modeling of heterogeneous treatment effects: scoping review of the impact of the PATH Statement.

ABSTRACT:

Background

The PATH Statement (2020) proposed predictive modeling for examining heterogeneity in treatment effects (HTE) in randomized clinical trials (RCTs). It distinguished risk modeling, which develops a multivariable model predicting individual baseline risk of study outcomes and examines treatment effects across risk strata, from effect modeling, which directly estimates individual treatment effects from models that include treatment, multiple patient characteristics and interactions of treatment with selected characteristics.

Purpose

To identify, describe and evaluate findings from reports that cite the Statement and present predictive modeling of HTE in RCTs.

Data extraction

We identified reports using PubMed, Google Scholar, Web of Science, SCOPUS through Jul

SUBMITTER: Selby JV 

PROVIDER: S-EPMC11100853 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature