Distinct eLPB^ChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference.

ABSTRACT: Methamphetamine (METH) withdrawal anxiety symptom and relapse have been significant challenges for clinical practice, however, the underlying neuronal basis remains unclear. Our recent research has identified a specific subpopulation of choline acetyltransferase (ChAT⁺) neurons localized in the external lateral portion of parabrachial nucleus (eLPB^ChAT), which modulates METH primed-reinstatement of conditioned place preference (CPP). Here, the anatomical structures and functional roles of eLPB^ChAT projections in METH withdrawal anxiety and primed reinstatement were further explored. Methods: In the present study, a multifaceted approach was employed to dissect the LPB^ChAT+ projections in male mice, including anterograde and retrograde trac

SUBMITTER: Chen W 

PROVIDER: S-EPMC11103501 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature