Employment of mastoparan-like peptides to prevent <i>Staphylococcus aureus</i> associated with bovine mastitis.

ABSTRACT: Bovine mastitis is a frequent infection in lactating cattle, causing great economic losses. Staphylococcus aureus represents the main etiological agent, which causes recurrent and persistent intramammary infections because conventional antibiotics are ineffective against it. Mastoparan-like peptides are multifunctional molecules with broad antimicrobial potential, constituting an attractive alternative. Nevertheless, their toxicity to host cells has hindered their therapeutic application. Previously, our group engineered three mastoparan-L analogs, namely mastoparan-MO, mastoparan-R1, and [I⁵, R⁸] MP, to improve cell selectivity and potential. Here, we were interested in comparing the antibacterial efficacy of mastoparan-L and its analogs against bovine mastiti

SUBMITTER: Orozco RMQ 

PROVIDER: S-EPMC11112992 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature