A late-life neurogenetic signature of exposure to combat stress - A monozygotic discordant twin study.

ABSTRACT: Animal models suggest that experiencing high-stress levels induces changes in amygdalar circuitry and gene expression. In humans, combat exposure has been shown to alter amygdalar responsivity and connectivity, but abnormalities have been indicated to normalize at least partially upon the termination of stress exposure. In contrast, other evidence suggests that combat exposure continues to exert influence on exposed individuals well beyond deployment and homecoming, as indicated by longitudinal psychosocial evidence from veterans, and observation of greater health decline in veterans late in life. Accordingly, the experience of combat stress early in life may affect amygdalar responsivity late in life, a possibility requiring careful consideration of the confounding effects of aging, genet

SUBMITTER: Beucke JC 

PROVIDER: S-EPMC11113072 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature