GlycA and CRP Are Genetically Correlated: Insight into the Genetic Architecture of Inflammageing.

ABSTRACT: Inflammageing is a condition of perpetual low-grade inflammation induced by ageing. Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described biomarker which measures N-glycosylated side chains of the carbohydrate component of several acute-phase proteins known as GlycA. The objective of this study was to examine in depth the genetic relationships between CRP and GlycA as well as between each of them and other selected cytokines, which may shed light on the mechanisms of inflammageing. Using the Olink 96 Inflammation panel, data on inflammatory mediators for 1518 twins from the TwinsUK dataset were acquired. Summary statistics for genome-wide association studies for several cytokines as well as CRP and GlycA were collected from public sources. Extensive gene

SUBMITTER: Kasher M 

PROVIDER: S-EPMC11117775 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature