Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study.

ABSTRACT: Both genetic and non-genetic factors contribute to individual variation in the immune response to vaccination. Understanding how genetic background influences variation in both magnitude and persistence of vaccine-induced immunity is vital for improving vaccine development and identifying possible causes of vaccine failure. Dogs provide a relevant biomedical model for investigating mammalian vaccine genetics; canine breed structure and long linkage disequilibrium simplify genetic studies in this species compared to humans. The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens, and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a

SUBMITTER: Blake JM 

PROVIDER: S-EPMC11144447 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature