Toward a more holistic approach to the study of exposures and child outcomes.

ABSTRACT: Aim: The current work was designed to demonstrate the application of the exposome framework in examining associations between exposures and children's long-term neurodevelopmental and behavioral outcomes. Methods: Longitudinal data were collected from birth through age 6 from 402 preterm infants. Three statistical methods were utilized to demonstrate the exposome framework: exposome-wide association study, cumulative exposure and machine learning models, with and without epigenetic data. Results: Each statistical approach answered a distinct research question regarding the impact of exposures on longitudinal child outcomes. Findings highlight associations between exposures, epigenetics and executive function. Conclusion: Findings demonstrate how an exposome-base

SUBMITTER: Lester BM 

PROVIDER: S-EPMC11157992 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature