Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model.

ABSTRACT: Young women have increased risk of vitamin D deficiency, which may increase breast cancer incidence. Here, we assessed the anti-cancer efficacy of vitamin D in mouse models of young-onset breast cancer. In never-pregnant mice, vitamin D supplementation increased serum 25(OH)D and hepatic 1,25(OH)₂D₃, reduced tumor size, and associated with anti-tumor immunity. These anti-tumor effects were not replicated in a mouse model of postpartum breast cancer, where hepatic metabolism of vitamin D was suppressed post-wean, which resulted in deficient serum 25(OH)D and reduced hepatic 1,25(OH)₂D₃. Treatment with active 1,25(OH)₂D₃ induced hypercalcemia exclusively in post-wean mice, highlighting metabolic imbalance post-wean. RNAseq rev

SUBMITTER: Bernhardt SM 

PROVIDER: S-EPMC11160686 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature