RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis.

ABSTRACT: The T cell population size is stringently controlled before, during, and after immune responses, as improper cell death regulation can result in autoimmunity and immunodeficiency. RIPK1 is an important regulator of peripheral T cell survival and homeostasis. However, whether different peripheral T cell subsets show a differential requirement for RIPK1 and which programmed cell death pathway they engage in vivo remains unclear. In this study, we demonstrate that conditional ablation of Ripk1 in conventional T cells (Ripk1^ΔCD4) causes peripheral T cell lymphopenia, as witnessed by a profound loss of naive CD4⁺, naive CD8⁺, and FoxP3⁺ regulatory T cells. Interestingly, peripheral naive CD8⁺ T cells in Ripk1^ΔCD4 mice appear to u

SUBMITTER: Huysentruyt J 

PROVIDER: S-EPMC11164875 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature