Molecular effects of indoor tanning.

ABSTRACT:

Background

Tanning bed users have a significantly increased risk of melanoma, but it remains unclear how indoor tanning drives melanomagenesis. Tanning bed radiation is often thought of as a substitute for natural UV radiation despite differences in the maximum doses, UV content, body sites exposed, and patterns of melanoma that arise.

Methods

To better understand the epidemiologic trends and etiology of melanoma associated with tanning bed use, we described the patterns of melanoma in patients with quantifiable tanning bed usage and performed exome sequencing of 182 melanocytes from normal skin of a subset of these patients.

Results

Tanning bed users were more likely than non-users to have melanoma on body sites with low cumulative levels of sun damage and were more

SUBMITTER: Gerami P 

PROVIDER: S-EPMC11185634 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature