Dual Metal Electrolysis in Theta Capillary for Lipid Analysis.

ABSTRACT: Increasing studies associating glycerophospholipids with various pathological conditions highlight the need for their thorough characterization. However, the intricate composition of the lipidome due to the presence of lipid isomers poses significant challenges to structural lipidomics. This study uses the anodic corrosion of two metals in a single theta nESI emitter as a tool to simultaneously characterize lipids at multiple isomer levels. Anodic corrosion of cobalt and copper in the positive ion mode generates the metal-adducted lipid complexes, [M+Co]²⁺ and [M+Cu]⁺, respectively. Optimization of parameters such as the distances of the electrodes from the nESI tip allowed the achievement of the formation of one metal-adducted lipid product at a time. Collision-induc

SUBMITTER: Sengupta A 

PROVIDER: S-EPMC11192522 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature