Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 <i>in vitro</i> and <i>in vivo</i> in NB xenografts.

ABSTRACT: The prognosis for children with recurrent and/or refractory neuroblastoma (NB) is dismal. The receptor tyrosine kinase-like orphan receptor 1 (ROR1), which is highly expressed on the surface of NB cells, provides a potential target for novel immunotherapeutics. Anti-ROR1 chimeric antigen receptor engineered ex vivo expanded peripheral blood natural killer (anti-ROR1 CAR exPBNK) cells represent this approach. N-803 is an IL-15 superagonist with enhanced biological activity. In this study, we investigated the in vitro and in vivo anti-tumor effects of anti-ROR1 CAR exPBNK cells with or without N-803 against ROR1⁺ NB models. Compared to mock exPBNK cells, anti-ROR1 CAR exPBNK cells had significantly enhanced cytotoxicity against ROR1⁺ NB cells, and N

SUBMITTER: Chu Y 

PROVIDER: S-EPMC11201149 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature