Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.

ABSTRACT:

Background & aims

Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that are not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened to develop the first evidence-based consensus recommendations for eoCRC.

Methods

After reviewing the published literature, a Delphi methodology was used to draft and respond to clinically relevant questions. Each statement underwent 3 rounds of voting and reached a consensus level of agreement of ≥80%.

Results

The DIRECt group produced 31 statements in 7 areas of interest: diagnosis, risk factors, genetics, pathology-oncology, endoscopy, therapy, and supportive care. There was strong consensus that all individuals younger than 50 should undergo CRC ris

SUBMITTER: Cavestro GM 

PROVIDER: S-EPMC11207185 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature