Beta-blocker use and breast cancer outcomes: a meta-analysis.

ABSTRACT:

Purpose

Beta blockers (BBs) are commonly used cardiovascular medications, and their association with breast cancer outcomes has been examined in several previous observational studies and meta-analyses. In this study, an updated meta-analysis was undertaken to ascertain the association between BBs and both breast cancer death (BCD) and breast cancer recurrence (BCR).

Methods

Articles were sourced from various databases up until the 14th of August 2023. Effect estimates were pooled using the random effects model, and the Higgins I² statistic was computed to ascertain heterogeneity. Subgroup analyses were conducted by the potential for immortal time bias (ITB), the exposure period (prediagnosis vs postdiagnosis), and type of BB (selective vs non-selective). Publicat

SUBMITTER: Scott OW 

PROVIDER: S-EPMC11208256 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature