Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients.

ABSTRACT:

Background

Over the last two decades, tumor-derived RNA expression signatures have been developed for the two most commonly diagnosed tumors worldwide, namely prostate and breast tumors, in order to improve both outcome prediction and treatment decision-making. In this context, molecular signatures gained by main components of the tumor microenvironment, such as cancer-associated fibroblasts (CAFs), have been explored as prognostic and therapeutic tools. Nevertheless, a deeper understanding of the significance of CAFs-related gene signatures in breast and prostate cancers still remains to be disclosed.

Methods

RNA sequencing technology (RNA-seq) was employed to profile and compare the transcriptome of CAFs isolated from patients affected by breast and prostate tumors. The di

SUBMITTER: Talia M 

PROVIDER: S-EPMC11210052 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature