Thymic stromal lymphopoietin induces IL-4/IL-13 from T cells to promote sebum secretion and adipose loss.

ABSTRACT:

Background

The cytokine TSLP promotes type 2 immune responses and can induce adipose loss by stimulating lipid loss from the skin through sebum secretion by sebaceous glands, which enhances the skin barrier. However, the mechanism by which TSLP upregulates sebaceous gland function is unknown.

Objectives

This study investigated the mechanism by which TSLP stimulates sebum secretion and adipose loss.

Methods

RNA-sequencing analysis was performed on sebaceous glands isolated by laser capture microdissection and single-cell RNA-sequencing analysis was performed on sorted skin T cells. Sebocyte function was analyzed by histological analysis and sebum secretion in vivo and by measuring lipogenesis and proliferation in vitro.

Results

This study found that TSLP sequent

SUBMITTER: Choa R 

PROVIDER: S-EPMC11211244 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature