Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study.

ABSTRACT:

Background and aims

Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) and health among the oldest-old (aged ≥80 years), as an inverse relationship of BMI with mortality was reported. This study was to investigate the causal associations of BMI, waist circumference (WC), or both with mortality in the oldest-old people in China.

Methods

A total of 5306 community-based oldest-old (mean age 90.6 years) were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 1998 and 2018. Genetic risk scores were constructed from 58 single-nucleotide polymorphisms (SNPs) associated with BMI and 49 SNPs associated with WC to subsequently derive causal estimates for Mendelian randomization (MR) models. One-sample linear MR

SUBMITTER: Lv Y 

PROVIDER: S-EPMC11212828 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature