ULK2 suppresses ovarian cancer cell migration and invasion by elevating IGFBP3.

ABSTRACT:

Background

Ovarian cancer is an aggressive malignancy with high mortality known for its considerable metastatic potential. This study aimed to explore the expression and functional role of Unc-51 like autophagy activating kinase 2 (ULK2) in the progression of ovarian cancer.

Methods

ULK2 expression patterns in ovarian cancer tissues as well as benign tumor control samples obtained from our institution were evaluated using immunohistochemistry. Cell counting kit 8 and Transwell assays were applied to assess the effects of ULK2 overexpression on cell proliferation, migration and invasion, respectively. RNA sequencing was performed to explore potential mechanisms of action of ULK2 beyond its classical autophagy modulation.

Results

Our experiments showed significant downr

SUBMITTER: Chen X 

PROVIDER: S-EPMC11216209 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature