Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans.

ABSTRACT:

Background

Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as risk for Alzheimer's disease and related dementias (ADRD). Overlapping symptom profiles observed in cognitive disorders, psychiatric disorders, and environmental exposures (e.g., head injury) can complicate the detection of early signs of ADRD. The interplay between PTSD, head injury, subjective (self-reported) cognitive concerns and genetic risk for ADRD is also not well understood, particularly in diverse ancestry groups.

Methods

Using data from the U.S. Department of Veterans Affairs (VA) Million Veteran Program (MVP), we examined the relationship between dementia risk factors (APOE ε4, PTSD, TBI) and subjective cognitive co

SUBMITTER: Neale ZE 

PROVIDER: S-EPMC11218206 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature