Novel probiotic preparation with in vivo gluten-degrading activity and potential modulatory effects on the gut microbiota.

ABSTRACT: Gluten possesses unique properties that render it only partially digestible. Consequently, it exerts detrimental effects on a part of the worldwide population who are afflicted with celiac disease (1%) or related disorders (5%), particularly due to the potential for cross-contamination even when adhering to a gluten-free diet (GFD). Finding solutions to break down gluten during digestion has a high nutritional and social impact. Here, a randomized double-blind placebo-controlled in vivo challenge investigated the gluten-degrading activity of a novel probiotic preparation comprising lactobacilli and their cytoplasmic extracts, Bacillus sp., and bacterial protease. In our clinical trial, we collected feces from 70 healthy volunteers at specific time intervals. Probiotic/placebo

SUBMITTER: Nikoloudaki O 

PROVIDER: S-EPMC11218521 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature