Risk of advanced neoplasia after removal of colorectal adenomas with high-grade dysplasia.

ABSTRACT:

Background

Many studies reported the presence of adenomas with high-grade dysplasia (HGD) at index colonoscopy increased the incidence of advanced neoplasia (AN) and colorectal cancer (CRC) following. However, the conclusion remains obscure due to lack of studies on the specific population of adenomas with HGD. This study aimed to assess the long-term risk of AN and CRC after removal of adenomas with HGD.

Methods

A total of 814 patients who underwent adenomas with HGD removal between 2010 and 2019 were retrospectively analyzed. The outcomes were the incidences of AN and CRC during surveillance colonoscopy. Cox proportional hazards models were utilized to identify risk factors associated with AN and CRC.

Results

During more than 2000 person-years of follow-up, we found

SUBMITTER: He D 

PROVIDER: S-EPMC11219408 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature