Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer's continuum.

ABSTRACT:

Background

Enlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer's disease (AD) and inversely correlated with cognitive performance. However, its clinical diagnostic and predictive value, and mechanisms by which ChP impacts the AD continuum remain unclear.

Methods

This prospective cohort study enrolled 607 participants [healthy control (HC): 110, mild cognitive impairment (MCI): 269, AD dementia: 228] from the Chinese Imaging, Biomarkers, and Lifestyle study between January 1, 2021, and December 31, 2022. Of the 497 patients on the AD continuum, 138 underwent lumbar puncture for cerebrospinal fluid (CSF) hallmark testing. The relationships between ChP volume and CSF pathological hallmarks (Aβ₄₂, Aβ₄₀, Aβ_42/40, tTau

SUBMITTER: Jiang J 

PROVIDER: S-EPMC11221040 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature