Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body.

ABSTRACT:

Background

The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural compartments such as the transparent vitreous body ensuring stability of the eye globe and a clear optical axis. Hyalocytes are the tissue-resident macrophages of the vitreous body and are considered to play pivotal roles in health and diseases of the vitreoretinal interface, such as proliferative vitreoretinopathy or diabetic retinopathy. However, in contrast to other ocular macrophages, their embryonic origin as well as the extent to which these myeloid cells might be replenished by circulating monocytes remains elusive.

Results

In this study, we combine transgenic reporter mice, embryonic and adult fate mapping approaches as we

SUBMITTER: Rosmus DD 

PROVIDER: S-EPMC11223341 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature