Risk of Bowel Obstruction in Patients Undergoing Neoadjuvant Chemotherapy for High-risk Colon Cancer: A Nested Case-control-matched Analysis of an International, Multicenter, Randomized Controlled Trial (FOxTROT).

ABSTRACT:

Objective

This study aimed to identify risk criteria available before the point of treatment initiation that can be used to stratify the risk of obstruction in patients undergoing neoadjuvant chemotherapy (NAC) for high-risk colon cancer.

Background

Global implementation of NAC for colon cancer, informed by the FOxTROT trial, may increase the risk of bowel obstruction.

Methods

A case-control study, nested within an international randomized controlled trial (FOxTROT; ClinicalTrials.gov: NCT00647530). Patients with high-risk operable colon cancer (radiologically staged T3-4 N0-2 M0) that were randomized to NAC and developed large bowel obstruction were identified. First, clinical outcomes were compared between patients receiving NAC in FOxTROT who did and did not develo

SUBMITTER: FOxTROT Collaborating Group 

PROVIDER: S-EPMC11224564 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature