MiR-425-5p suppression of Crebzf regulates oocyte aging via chromatin modification.

ABSTRACT: Female infertility due to declining oocyte quality with age remains a significant challenge for patients and physicians, despite extensive research efforts. Recent studies suggest that microRNAs (miRNAs), which respond to various stressors in the aging process, may provide a promising solution. With the approval of small RNA drugs for clinical use, miRNA-based treatment of oocyte aging appears to be a viable option. Through high-throughput sequencing, miR-425-5p was identified as the only miRNA elevated under natural aging and oxidative stress. Microinjection of inhibitors to inhibit miR-425-5p effectively improved compromised phenotypes of old oocytes in vitro. Further investigation revealed that Crebzf acts as a mediator of miR-425-5p's age-related functions in old oocytes. In vivo treat

SUBMITTER: Jueraitetibaike K 

PROVIDER: S-EPMC11226420 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature