The effect of rifaximin and lactulose treatments to chronic hepatic encephalopathy rats: An [¹⁸F]PBR146 in-vivo neuroinflammation imaging study.

ABSTRACT:

Introduction

Hepatic encephalopathy (HE) is a severe neuropsychiatric complication of liver diseases characterized by neuroinflammation. The efficacies of nonabsorbable rifaximin (RIF) and lactulose (LAC) have been well documented in the treatment of HE. [¹⁸F]PBR146 is a translocator protein (TSPO) radiotracer used for in vivo neuroinflammation imaging. This study investigated anti-neuroinflammation effect of RIF or/and LAC in chronic HE rats by [¹⁸F]PBR146 micro-PET/CT.

Methods

Bile duct ligation (BDL) operation induced chronic HE models, and this study included Sham+normal saline (NS), BDL+NS, BDL+RIF, BDL+LAC, and BDL+RIF+LAC groups. Behavioral assessment was performed to analyze the motor function, and fecal samples were collected after successfully

SUBMITTER: Kong X 

PROVIDER: S-EPMC11226542 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature