Ontology highlight
ABSTRACT:
SUBMITTER: Wong AC
PROVIDER: S-EPMC11227373 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Wong Andrea C AC Devason Ashwarya S AS Umana Iboro C IC Cox Timothy O TO Dohnalová Lenka L Litichevskiy Lev L Perla Jonathan J Lundgren Patrick P Etwebi Zienab Z Izzo Luke T LT Kim Jihee J Tetlak Monika M Descamps Hélène C HC Park Simone L SL Wisser Stephen S McKnight Aaron D AD Pardy Ryan D RD Kim Junwon J Blank Niklas N Patel Shaan S Thum Katharina K Mason Sydney S Beltra Jean-Christophe JC Michieletto Michaël F MF Ngiow Shin Foong SF Miller Brittany M BM Liou Megan J MJ Madhu Bhoomi B Dmitrieva-Posocco Oxana O Huber Alex S AS Hewins Peter P Petucci Christopher C Chu Candice P CP Baraniecki-Zwil Gwen G Giron Leila B LB Baxter Amy E AE Greenplate Allison R AR Kearns Charlotte C Montone Kathleen K Litzky Leslie A LA Feldman Michael M Henao-Mejia Jorge J Striepen Boris B Ramage Holly H Jurado Kellie A KA Wellen Kathryn E KE O'Doherty Una U Abdel-Mohsen Mohamed M Landay Alan L AL Keshavarzian Ali A Henrich Timothy J TJ Deeks Steven G SG Peluso Michael J MJ Meyer Nuala J NJ Wherry E John EJ Abramoff Benjamin A BA Cherry Sara S Thaiss Christoph A CA Levy Maayan M
Cell 20231016 22
Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated to explain the etiology of PASC, including viral persistence, chronic inflammation, hypercoagulability, and autonomic dysfunction. Here, we propose a mechanism that links all four hypotheses in a single pathway and provides actionable insights for therapeutic interventions. We ...[more]