Multi-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis.

ABSTRACT: Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are Philadelphia chromosome-negative myeloproliferative neoplasms. These conditions share overlapping clinical presentations; however, their prognoses differ significantly. Current morphological diagnostic methods lack reliability in subtype differentiation, underlining the need for improved diagnostics. The aim of this study was to investigate the multi-omics alterations in bone marrow biopsies of patients with ET and pre-PMF to improve our understanding of the nuanced diagnostic characteristics of both diseases. We performed proteomic analysis with 4D direct data-independent acquisition and microbiome analysis with 2bRAD-M sequencing technology to identify differential protein and microbe levels between untrea

SUBMITTER: Zhang A 

PROVIDER: S-EPMC11228008 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature