Identification of novel genes associated with atherosclerosis in Bama miniature pig.

ABSTRACT:

Background

Atherosclerosis is a chronic cardiovascular disease of great concern. However, it is difficult to establish a direct connection between conventional small animal models and clinical practice. The pig's genome, physiology, and anatomy reflect human biology better than other laboratory animals, which is crucial for studying the pathogenesis of atherosclerosis.

Methods

We used whole-genome sequencing data from nine Bama minipigs to perform a genome-wide linkage analysis, and further used bioinformatic tools to filter and identify underlying candidate genes. Candidate gene function prediction was performed using the online prediction tool STRING 12.0. Immunohistochemistry and immunofluorescence were used to detect the expression of proteins encoded by candidate genes.

SUBMITTER: Ding D 

PROVIDER: S-EPMC11228093 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature