Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time.

ABSTRACT:

Background

Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance.

Methods

Data from two decades (2000-2020) of continuous molecular surveillance of P. falciparum parasites from Senegal were retrospectively examined to assess historical changes in malaria drug resistance mutations. Several known drug resistance markers and their surrounding haplotypes were profiled using a combination of single nucleotide polymorphism (SNP) molecular surveillance and whole genome sequence based population genomics.

Results

This dataset was used to track temporal changes in drug resistance markers whose timing correspond to historically signific

SUBMITTER: Ndiaye YD 

PROVIDER: S-EPMC11234717 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature