Novel pentafluorosulfanyl-containing triclocarban analogs selectively kill Gram-positive bacteria.

ABSTRACT: Novel antimicrobial agents are needed to combat antimicrobial resistance. This study tested novel pentafluorosulfanyl-containing triclocarban analogs for their potential antibacterial efficacy. Standard procedures were used to produce pentafluorosulfanyl-containing triclocarban analogs. Twenty new compounds were tested against seven Gram-positive and Gram-negative indicator strains as well as 10 clinical isolates for their antibacterial and antibiofilm activity. Mechanistic investigations focused on damage to cell membrane, oxidizing reduced thiols, iron-sulfur clusters, and oxidative stress to explain the compounds' activity. Safety profiles were assessed using cytotoxicity experiments in eukaryotic cell lines. Following screening, selected components had significantly better antibacteria

SUBMITTER: Pormohammad A 

PROVIDER: S-EPMC11237694 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature