Metabolic programs of T cell tissue residency empower tumour immunity.

ABSTRACT: Tissue resident memory CD8⁺ T (T_RM) cells offer rapid and long-term protection at sites of reinfection¹. Tumour-infiltrating lymphocytes with characteristics of T_RM cells maintain enhanced effector functions, predict responses to immunotherapy and accompany better prognoses^2,3. Thus, an improved understanding of the metabolic strategies that enable tissue residency by T cells could inform new approaches to empower immune responses in tissues and solid tumours. Here, to systematically define the basis for the metabolic reprogramming supporting T_RM cell differentiation, survival and function, we leveraged in vivo functional genomics, untargeted metabolomics and transcriptomics of virus-specific memory CD8⁺ T cell po

SUBMITTER: Reina-Campos M 

PROVIDER: S-EPMC11238873 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature