PYPE: A pipeline for phenome-wide association and Mendelian randomization in investigator-driven biobank scale analysis.

ABSTRACT: Phenome-wide association studies (PheWASs) serve as a way of documenting the relationship between genotypes and multiple phenotypes, helping to uncover unexplored genotype-phenotype associations (known as pleiotropy). Secondly, Mendelian randomization (MR) can be harnessed to make causal statements about a pair of phenotypes by comparing their genetic architecture. Thus, approaches that automate both PheWASs and MR can enhance biobank-scale analyses, circumventing the need for multiple tools by providing a comprehensive, end-to-end tool to drive scientific discovery. To this end, we present PYPE, a Python pipeline for running, visualizing, and interpreting PheWASs. PYPE utilizes input genotype or phenotype files to automatically estimate associations between the chosen independent variable

SUBMITTER: Dalal T 

PROVIDER: S-EPMC11240175 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature