Nanoreporter Identifies Lysosomal Storage Disease Lipid Accumulation Intracranially.

ABSTRACT: Dysregulated lipid metabolism contributes to neurodegenerative pathologies and neurological decline in lysosomal storage disorders as well as more common neurodegenerative diseases. Niemann-Pick type A (NPA) is a fatal neurodegenerative lysosomal storage disease characterized by abnormal sphingomyelin accumulation in the endolysosomal lumen. The ability to monitor abnormalities in lipid homeostasis intracranially could improve basic investigations and the development of effective treatment strategies. We investigated the carbon nanotube-based detection of intracranial lipid content. We found that the near-infrared emission of a carbon nanotube-based lipid sensor responds to lipid accumulation in neuronal and in vivo models of NPA. The nanosensor detected lipid accumulation intracranially i

SUBMITTER: Antman-Passig M 

PROVIDER: S-EPMC11246544 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature