Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration.
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SUBMITTER: Pazur EJ
PROVIDER: S-EPMC11247652 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
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Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration.
Pazur Ethan J EJ Kalatanova Anna A Tasker Nikhil R NR Vainionpää Katri K Leinonen Henri H Wipf Peter P
ACS medicinal chemistry letters 20240613 7
Iso-dimethyltryptamine (isoDMT) analogues with heterocyclic substitutions at the indole C(3) were prepared in a hydrogen autotransfer alkylation and tested in combination with natural and unnatural clavine alkaloids in a model of light-induced retinal degeneration for protection against retinal degeneration. On the basis of measurements with optical coherence tomography and electroretinography, three compounds showed better efficacy than the positive control bromocriptine at equivalent systemica ...[more]
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