The risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis.

ABSTRACT:

Introduction

The cognitive impairment patterns and the association with Alzheimer's disease (AD) in mental disorders remain poorly understood.

Methods

We analyzed data from 486,297 UK Biobank participants, categorizing them by mental disorder history to identify the risk of AD and the cognitive impairment characteristics. Causation was further assessed using Mendelian randomization (MR).

Results

AD risk was higher in individuals with bipolar disorder (BD; hazard ratio [HR] = 2.37, P < 0.01) and major depressive disorder (MDD; HR = 1.63, P < 0.001). MR confirmed a causal link between BD and AD (OR_IVW = 1.098), as well as obsessive-compulsive disorder (OCD) and AD (OR_IVW = 1.050). Cognitive impairments varied, with BD and schizophrenia showing wide

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11247675 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature