Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury.
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ABSTRACT:
SUBMITTER: Subramanian A
PROVIDER: S-EPMC11249042 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Publications
Protective role for kidney TREM2<sup>high</sup> macrophages in obesity- and diabetes-induced kidney injury.
Subramanian Ayshwarya A Vernon Katherine A KA Zhou Yiming Y Marshall Jamie L JL Alimova Maria M Arevalo Carlos C Zhang Fan F Slyper Michal M Waldman Julia J Montesinos Monica S MS Dionne Danielle D Nguyen Lan T LT Cuoco Michael S MS Dubinsky Dan D Purnell Jason J Keller Keith K Sturner Samuel H SH Grinkevich Elizabeth E Ghoshal Ayan A Kotek Amanda A Trivioli Giorgio G Richoz Nathan N Humphrey Mary B MB Darby Isabella G IG Miller Sarah J SJ Xu Yingping Y Weins Astrid A Chloe-Villani Alexandra A Chang Steven L SL Kretzler Matthias M Rosenblatt-Rosen Orit O Shaw Jillian L JL Zimmerman Kurt A KA Clatworthy Menna R MR Regev Aviv A Greka Anna A
Cell reports 20240522 6
Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profiles from DKD patients and two DKD mouse models at multiple time points along disease progression-high-fat diet (HFD)-fed mice aged to 90-100 weeks and BTBR ob/ob mice (a genetic model)-and report an expanding population of macrophages with high expression of tr ...[more]
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