Ontology highlight
ABSTRACT:
SUBMITTER: Moqri M
PROVIDER: S-EPMC11250797 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Nature communications 20240716 1
DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm gain is less characterized. Studies have demonstrated that CpGs which gain methylation with age are enriched in Polycomb Repressive Complex 2 (PRC2) targets. However, whole-genome examination of all PRC2 targets as well as determination of the pan-tissue or tissue-specific nature of these associations is lacking. Here, we s ...[more]