Association of serum Spp1 levels with disease progression in ALS and SBMA.

ABSTRACT:

Objective

In comparison with amyotrophic lateral sclerosis (ALS), the contribution of neuroinflammation in spinobulbar muscular atrophy (SBMA) has been less explored. We investigated the role of neuroinflammation in the pathogenesis of ALS and SBMA by analyzing systemic inflammatory markers and osteopontin (Spp1).

Methods

This study involved 105 ALS, 77 SBMA, and 55 healthy controls. We measured their systemic inflammatory markers, serum Spp1, and cytokine levels (interferon-γ, interleukin [IL]-1β, IL-6, IL-8, IL-10, tumor necrosis factor-α, and IL-17A), investigated correlations between Spp1 levels and clinical features, and evaluated ALS survival rates according to Spp1 levels.

Results

In the ALS group, systemic inflammatory markers were significantly higher than in

SUBMITTER: Ju W 

PROVIDER: S-EPMC11251464 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature