Label-Free Metal-Oxide Transistor Biosensors for Metabolite Detection in Human Saliva.

ABSTRACT: Metabolites are essential molecules involved in various metabolic processes, and their deficiencies and excessive concentrations can trigger significant physiological consequences. The detection of multiple metabolites within a non-invasively collected biofluid could facilitate early prognosis and diagnosis of severe diseases. Here, a metal oxide heterojunction transistor (HJ-TFT) sensor is developed for the label-free, rapid detection of uric acid (UA) and 25(OH)Vitamin-D3 (Vit-D3) in human saliva. The HJ-TFTs utilize a solution-processed In₂O₃/ZnO channel functionalized with uricase enzyme and Vit-D3 antibody for the selective detection of UA and Vit-D3, respectively. The ultra-thin tri-channel architecture facilitates strong coupling between the electrons transport

SUBMITTER: Sharma A 

PROVIDER: S-EPMC11251559 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature