Comorbid neuropathology and atypical presentation of Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) neuropathological changes present with amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid neuropathology as a substratum of atypical expression of AD remains under investigated.

Methods

We examined whether atypical AD exhibited increased comorbid neuropathology compared to typical AD and if such neuropathologies contributed to the accelerated clinical decline in atypical AD.

Results

We examined 60 atypical and 101 typical AD clinicopathological cases. The number of comorbid pathologies was similar between the groups (p = 0.09). Argyrophilic grain disease was associated with atypical presentation (p = 0.008) after accounting for sex, age of onset, and disease duration. Vascular brain injury wa

SUBMITTER: Pina-Escudero SD 

PROVIDER: S-EPMC11262028 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature