The Influence of the FFAR4 Agonist TUG-891 on Liver Steatosis in ApoE-Knockout Mice.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) constitutes an independent risk factor for the development of coronary heart disease. Low-grade inflammation has been shown to play an important role in the development of atherosclerosis and NAFLD. Free fatty acid receptor 4 (FFAR4/GPR120), which is involved in damping inflammatory reactions, may represent a promising target for the treatment of inflammatory diseases. Our objective was to evaluate the effect of TUG-891, the synthetic agonist of FFAR4/GPR120, on fatty liver in vivo.

Methods

The effect of TUG-891 on fatty liver was investigated in apoE^-/- mice fed a high-fat diet (HFD), using microscopic, biochemical, molecular, and proteomic methods.

Results

Treatment with TUG-891 inhibited the progression

SUBMITTER: Kiepura A 

PROVIDER: S-EPMC11266261 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature