Parkinson's disease psychosis associated with accelerated multidomain cognitive decline.

ABSTRACT:

Background

Cognitive deficits are associated with poor quality of life and increased risk of development of dementia in patients with Parkinson's disease (PD) psychosis. The trajectory of cognitive decline in PD psychosis remains however unclear.

Objective

We examined this using data from the Parkinson's Progression Markers Initiative study.

Methods

We analysed data from patients with drug-naïve PD (n=676) and healthy controls (HC, n=187) over 5 years, and examined all cognitive measures assessed at each time point. We classified patients with PD into those who developed psychosis over the course of the study (PDP) and those without psychosis throughout (PDnP) using the Movement Disorders Society Unified Parkinson's Disease Rating Scale part I hallucinations/psychosis

SUBMITTER: Pisani S 

PROVIDER: S-EPMC11268075 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature