Dataset Information

Mendelian randomization of stroke risk after total hip and knee replacements.

ABSTRACT:

Objective

Previous epidemiological studies have indicated an increased risk of neurovascular diseases in patients following total hip and knee replacements. However, definitive conclusions regarding the increased risk of stroke post-replacement remain elusive. Therefore, we conducted a two-sample Mendelian randomization study to investigate the causal relationship between total hip and knee replacements and stroke.

Methods

We utilized summary data from publicly available genome-wide association studies (GWAS). Data concerning total hip replacements (THR, N = 319,037) and total knee replacements (TKR, N = 252,041) were sourced from the Genetics of Osteoarthritis (GO) Consortium. Stroke-related data were obtained from the International Stroke Genetics Consortium, encompassing any stroke (AS), any ischemic stroke (AIS), large vessel ischemic stroke (LV-IS), cardioembolic ischemic stroke (CE-IS), and small vessel ischemic stroke (SV-IS). Our primary causal inference method was the inverse variance weighted (IVW) approach, supplemented by weighted median and MR-Egger regression as secondary inference methods. We utilized the MR-PRESSO global test for outlier detection, Cochran's Q statistic to assess heterogeneity, and assessed the multiplicity and stability of our findings using p-values from MR-PRESSO and MR-Egger regressions, and the leave-one-out method, respectively.

Results

We identified significant genetic associations between THR and both AS (IVW p = 0.0001, OR = 1.08, 95% CI = 1.04-1.12) and AIS (IVW p = 0.0016, OR = 1.07, 95% CI = 1.03-1.12). Significant associations were also observed between TKR and AS (IVW p = 0.0002, OR = 1.08, 95% CI = 1.04-1.12), as well as AIS (IVW p = 0.0005, OR = 1.15, 95% CI = 1.06-1.24).

Conclusion

Our findings genetically support an increased risk of stroke following total hip and knee replacements. However, further studies are necessary to elucidate the specific mechanisms underlying stroke episodes post-replacement.

SUBMITTER: Pang L

PROVIDER: S-EPMC11270026 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Mendelian randomization of stroke risk after total hip and knee replacements.

Pang Liang L Zheng Zhihui Z Su Pingping P Xu Zhouhengte Z Chen Yirui Y Liao Zhicheng Z Jia Pengcheng P Zhang Xiuling X Lv Cunxian C

Frontiers in genetics 20240711

<h4>Objective</h4>Previous epidemiological studies have indicated an increased risk of neurovascular diseases in patients following total hip and knee replacements. However, definitive conclusions regarding the increased risk of stroke post-replacement remain elusive. Therefore, we conducted a two-sample Mendelian randomization study to investigate the causal relationship between total hip and knee replacements and stroke.<h4>Methods</h4>We utilized summary data from publicly available genome-wi ...[more]

PMID: 39055256

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Dataset Information

Mendelian randomization of stroke risk after total hip and knee replacements.

Objective

Methods

Results

Conclusion

Publications

Mendelian randomization of stroke risk after total hip and knee replacements.

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