Understanding the Foreign Body Response via Single-Cell Meta-Analysis.

ABSTRACT: Foreign body response (FBR) is a universal reaction to implanted biomaterial that can affect the function and longevity of the implant. A few studies have attempted to identify targets for treating FBR through the use of single-cell RNA sequencing (scRNA-seq), though the generalizability of these findings from an individual study may be limited. In our study, we perform a meta-analysis of scRNA-seq data from all available FBR mouse studies and integrate these data to identify gene signatures specific to FBR across different models and anatomic locations. We identify subclusters of fibroblasts and macrophages that emerge in response to foreign bodies and characterize their signaling pathways, gene ontology terms, and downstream mediators. The fibroblast subpopulations enriched in the settin

SUBMITTER: Liang NE 

PROVIDER: S-EPMC11273435 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature