Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.

ABSTRACT:

Background

The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. These effects include differences in DNA methylation (DNAm), an important form of epigenetic gene regulation, at multiple CpG loci across the genome. Moreover, these effects can be shared or specific to both central and peripheral tissues. Here, we aim to identify blood DNAm differences associated with PTSD and characterize the underlying biological mechanisms by examining the extent to which they mirror associations across multiple brain regions.

Methods

As the Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup, we conducted t

SUBMITTER: Katrinli S 

PROVIDER: S-EPMC11275670 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature