Exploring the impact of body mass index on tumor biology and cancer development.

ABSTRACT:

Purpose

Cancer continues to be a major global health challenge, affecting millions of individuals and placing substantial burdens on healthcare systems worldwide. Recent research suggests a complex relationship between obesity and cancer, with obesity increasing the risk of various cancers while potentially improving outcomes for diagnosed patients, a phenomenon termed the "obesity paradox". In this study, we used a cohort of 1781 patients to investigate the impact of obesity on tumor characteristics, including gene expression, pathway dysfunction, genetic alterations and immune infiltration.

Methods

Patient samples spanned 10 different cancer types, and were obtained from the Cancer Genome Atlas, with annotations for body mass index (BMI), age, sex, tumor size and tumor gen

SUBMITTER: Ahrenfeldt J 

PROVIDER: S-EPMC11283407 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature